University of Michigan-Ann Arbor · BiologyIntestinal Barrier Research Lab
Charles A Parkos · Ann Arbor, Michigan
Research Focus
Dr. Charles A Parkos at the University of Michigan focuses on understanding how HIV infection disrupts the intestinal barrier, leading to inflammation and various health complications in people living with HIV. His lab investigates the interaction between HIV-infected cells and intestinal epithelial cells, aiming to uncover the molecular pathways that contribute to these diseases. By tackling these issues, the lab hopes to develop targeted therapies that can improve overall health for individuals affected by HIV.
HIVIntestinal barrierInflammationCytokinesMucosal healing
Research Aims
5AIM 01Determine how HIV infection disrupts intestinal barrier function.
AIM 02Identify pathways altered in intestinal epithelial cells exposed to HIV.
AIM 03Investigate the role of innate immune cells in intestinal inflammation and repair.
AIM 04Analyze the interactions between CD4+ T cells and intestinal epithelial cells during HIV infection.
AIM 05Explore therapeutic targets to improve wound healing in the intestines.
Skills the Lab Values
Cell cultureFlow cytometryWestern blotRNA sequencingMicroscopy
Output against the department
Publications418top 11% of dept.112th of 1,033
this lab
most publishedleast published
Citations25ktop 15% of dept.155th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.