Ohio State University-Main Campus · ChemistryPei Pharmacotherapy Lab
Dehua Pei · Columbus, Ohio
Research Focus
Dehua Pei's lab at Ohio State University focuses on creating new types of drugs capable of targeting previously untreatable human diseases caused by genetic mutations and problematic protein interactions. By developing cell-permeable peptides and proteins, the lab aims to improve drug delivery into cells, potentially opening new avenues in pharmacotherapy. Their research combines aspects of chemistry, biology, and medicine to innovate solutions that could help many people suffering from genetic diseases.
cell-permeable peptidesdrug deliveryhuman genetic diseasesprotein-protein interactionsbiologicscyclic peptidesendocytic uptakepharmaceutical developmenttherapeutics
Research Aims
5AIM 01Develop cell-permeable peptides for drug delivery into mammalian cells.
AIM 02Investigate the mechanisms of how peptides and proteins enter cells.
AIM 03Create targeted delivery systems for tumor tissues using engineered peptides.
AIM 04Establish new chemical probes for studying protein interactions and functions.
AIM 05Explore unconventional protein secretion mechanisms in mammalian cells.
Skills the Lab Values
cell cultureprotein purificationfluorescence microscopyconfocal microscopyendocytosis assaysprotein engineeringpeptide synthesisanimal modelsmolecular dynamics simulation
Output against the department
Publications195bottom 46% of dept.116th of 216
this lab
most publishedleast published
Citations9.7ktop 49% of dept.105th of 216
this lab
most citedleast cited
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