Icahn School of Medicine at Mount Sinai · GeneticsRNA Modifications and Neuroinflammation Lab
Panagiotis Roussos · New York, New York
Research Focus
Dr. Panagiotis Roussos' lab focuses on understanding the role of RNA modifications in the brain, particularly in relation to Alzheimer's Disease (AD). They study how changes in RNA impact the immune cells of the brain, known as microglia, which are critical in neuroinflammation and AD progression. By utilizing advanced genomic techniques, the lab aims to uncover new insights that could lead to potential therapies for AD and related conditions.
Alzheimer's Diseasemicrogliam6A RNA modificationsneuroinflammationCRISPRepigeneticsRNA sequencinghuman induced pluripotent stem cellspathogenesistherapeutic targets
Research Aims
4AIM 01Profile m6A RNA modifications in microglia from Alzheimer's Disease and control brain tissues.
AIM 02Utilize CRISPR-based methods to perturb m6A regulatory proteins in microglia and analyze the effects on their functions.
AIM 03Assess the impact of RNA modifications on gene expression and neuroinflammation in microglia.
AIM 04Map the interactions of m6A modifications with genetic risk loci associated with Alzheimer's Disease.
Skills the Lab Values
RNA sequencingCRISPR/Cas technologycell culturemicroglial cell modelsgene expression analysisphagocytosis assayscytokine measurementRNA modification profilingbioinformatics analysisfunctional genomic assays
Output against the department
Publications32bottom 5% of dept.245th of 259
this lab
most publishedleast published
Citations3.8kbottom 19% of dept.209th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.