Washington University in St Louis · NeuroscienceMcDade Lab
Eric Martin Mcdade · Saint Louis, Missouri
Research Focus
Dr. Eric McDade's lab at Washington University focuses on Alzheimer's disease, specifically testing if early intervention can prevent the onset of the disease in individuals with a genetic predisposition. The lab conducts clinical trials aimed at stopping amyloid plaque formation, which is associated with Alzheimer's pathology, by using innovative anti-amyloid therapies. Their research seeks to radically change how Alzheimer's is approached, making it possible to intervene before symptoms appear.
Alzheimer's diseaseamyloid plaquescognitive healthclinical trialsneurodegenerationpreventive therapiesgenetic predispositionbiomarkerspublic health
Research Aims
4AIM 01Investigate the prevention of amyloid deposition in Alzheimer's disease mutation carriers.
AIM 02Test the efficacy of anti-amyloid therapies in asymptomatic individuals.
AIM 03Evaluate cognitive outcomes in participants receiving early intervention.
AIM 04Explore the impact of preventing amyloid pathology on disease progression.
Skills the Lab Values
clinical trial designpatient recruitmentbiomarker analysisPET imagingdata collectionrandomized control methodsstatistical analysisethics in researchcognitive assessment
Output against the department
Publications453top 13% of dept.86th of 671
this lab
most publishedleast published
Citations22ktop 19% of dept.125th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.