University of Michigan-Ann Arbor · Mathematics & StatisticsThe Differentiation Lab
Joshua Welch · Ann Arbor, Michigan
Research Focus
Dr. Joshua Welch's lab at the University of Michigan focuses on understanding how cells differentiate into their specialized forms by using advanced computational techniques. They analyze data from new technologies that profile gene expression and epigenomes in single cells to model how cells change over time. By developing tools that combine various types of data, the lab aims to create predictive models that can help address disease-related issues in cell differentiation.
cell differentiationsingle-cell sequencingmulti-omic dataepigenomicscomputational modeling
Research Aims
3AIM 01Develop models for how epigenomic layers and RNA change during cell fate transitions.
AIM 02Incorporate spatial relationships of cells into models of cell differentiation.
AIM 03Use single-cell perturbation techniques to study effects on cell fate transitions.
Skills the Lab Values
data analysismulti-omic data integrationcomputational modelingdifferential equationsCRISPR perturbation techniques
Output against the department
Publications129bottom 24% of dept.100th of 131
this lab
most publishedleast published
Citations7.9ktop 49% of dept.64th of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.