University of California-Irvine · Microbiology & ImmunologyGene Regulation and Immunity Unit
Yongsheng Shi · Irvine, California
Research Focus
Dr. Yongsheng Shi's lab at UC Irvine focuses on understanding the processes that control how genes are expressed at the molecular level, particularly through mechanisms called alternative polyadenylation (APA) and alternative splicing. The research is particularly interested in how these processes affect B cell development and function, which are critical for the immune response. By uncovering the regulatory networks involved, the lab aims to provide insights that could lead to improved treatments for autoimmune diseases and cancer.
alternative polyadenylationB cell developmentgene regulationRNA processingautoimmune diseasesmRNAcancerimmunitytranscription factorsmachine learning
Research Aims
3AIM 01Identify regulators of B cell activation-induced IghM APA switch.
AIM 02Characterize the mechanisms of B cell activation-induced IghM APA switch.
AIM 03Determine the role of APA regulation in B cell activation and differentiation.
Skills the Lab Values
cell cultureRNA sequencingbiochemical assaysmassively parallel reporter assaysgenetic manipulationmachine learningdata analysisPCRWestern blotflow cytometry
Output against the department
Publications133top 48% of dept.231st of 486
this lab
most publishedleast published
Citations5.1kbottom 38% of dept.301st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.