Washington University in St Louis · NeuroscienceAutoimmune T Cell Dynamics Lab
Naresha Saligrama · Saint Louis, Missouri
Research Focus
Dr. Naresha Saligrama's research lab at Washington University focuses on understanding the immune responses involved in autoimmune diseases, particularly multiple sclerosis (MS) and the roles of specific T cells. They investigate how certain immune T cell receptors react with both myelin and viral antigens, aiming to uncover the triggers of MS. Additionally, the lab explores the function of unique regulatory T cells that could provide insights for treating autoimmune conditions.
Multiple SclerosisAutoimmunityT cell receptorsCD8 T cellsLy49 receptorsCross-reactivityTransgenic miceCerebrospinal fluidImmune responseViral infections
Research Aims
5AIM 01Assess the cross-reactive CD4 TCR repertoire between myelin and viral peptides in MS patients and healthy individuals.
AIM 02Investigate the impact of cross-reactive CD4 TCRs in a mouse model for multiple sclerosis.
AIM 03Identify how Ly49 receptors influence the function of CD8 regulatory T cells.
AIM 04Examine the role of IL-15 in regulating CD8 Treg responses.
AIM 05Determine the relevance of Ly49+ CD8 Tregs in human autoimmune diseases.
Skills the Lab Values
Single cell TCR sequencingMouse modelsFlow cytometryCell culture techniquesBiological assaysTransgenic organism generationImmunological assaysAntigen discoveryData analysis using algorithmsPCR
Output against the department
Publications55bottom 13% of dept.583rd of 671
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.512th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.