Yale University · GeneticsReilly Genomics Lab
Steven K. Reilly · New Haven, Connecticut
Research Focus
Dr. Steven K. Reilly's lab at Yale University focuses on understanding how variations in human DNA can affect traits and diseases. By studying and cataloging genetic mutations in regulatory regions of the genome, the lab aims to uncover the mechanisms behind these variations and improve predictions about their impacts on human health. The research combines advanced techniques like CRISPR and machine learning to investigate the complex interactions between genes and regulatory elements, leading to insights that could enhance our understanding of genetic diseases.
genetic variationCRISPRhuman healthmachine learningregulatory elementstranscriptional regulationepigeneticsgenome mappingdisease traitsfunctional genomics
Research Aims
5AIM 01Identify functional regulatory variants associated with human traits.
AIM 02Build a comprehensive catalog of regulatory mutations and their effects.
AIM 03Investigate the interaction between cis-regulatory elements and transcription.
AIM 04Develop machine learning models to predict mutation impacts on health.
AIM 05Understand the regulatory grammar governing gene expression.
Skills the Lab Values
CRISPR/Cas technologyChIP-sequencingmultiplexed amplicon sequencingsaturation mutagenesisflow cytometrydata modelingfunctional characterizationstatistical geneticsgenome-wide association studiesbioinformatics
Output against the department
Publications70bottom 17% of dept.215th of 259
this lab
most publishedleast published
Citations7.2kbottom 38% of dept.160th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.