Stanford University · GeneticsSteinmetz Lab
Lars M Steinmetz · Stanford, California
Research Focus
Dr. Lars M Steinmetz's lab at Stanford University focuses on understanding how genetic variations affect gene regulation and expression. By using advanced techniques like CRISPR and single-cell transcriptomics, the lab aims to uncover the complex networks that control how genes function and contribute to disease. This research could lead to better predictions about individual disease risks and more effective treatments based on genetic information.
CRISPRgenetic variationgene regulationsingle-cell transcriptomicsprecision medicinefunctional genomicsmachine learninggenome editingregulatory networks
Research Aims
5AIM 01Investigate the functional relevance of genetic variants across the human genome.
AIM 02Develop and apply CRISPR/Cas9 functional genomics screening technologies.
AIM 03Characterize regulatory networks governing gene expression using single-cell transcriptomic readouts.
AIM 04Train machine learning models to predict genetic regulatory interactions across cell types.
AIM 05Experimental validation of predicted gene regulatory impacts of genetic variation.
Skills the Lab Values
CRISPR/Cas9single-cell RNA sequencinggenome editingdata integrationtranscription factor binding assays (ChIP-seq)chromatin accessibility assays (ATAC-seq)Hi-Ccomputational modelinghigh-throughput screening
Output against the department
Publications401top 17% of dept.45th of 259
this lab
most publishedleast published
Citations37ktop 17% of dept.43rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.