University of California-Berkeley · BiochemistryBarton Lab
Gregory M Barton · Berkeley, California
Research Focus
Dr. Gregory Barton's research lab at UC Berkeley is focused on understanding how the immune system differentiates between self and non-self nucleic acids to prevent autoimmune diseases. His team studies Toll-like receptors (TLRs), especially TLR7 and TLR9, which are critical in regulating immune responses. They are exploring how specific proteins and external signals affect these receptors' functions, with the goal of developing better therapies for autoimmune conditions and enhancing tissue repair processes.
Toll-like receptorsautoimmunityT regulatory cellsnucleic acidscellular signalingCRISPRimmune responsetissue repairself versus non-self discriminationgenome-wide screening
Research Aims
3AIM 01Define how Unc93b1 regulates TLR7 signaling and its implications for autoimmunity
AIM 02Characterize pathways limiting TLR7 responses to self RNA based on CRISPR screen results
AIM 03Investigate how TLR9 regulates responses to self DNA and its role in autoimmunity
Skills the Lab Values
cell cultureCRISPRgenome-wide CRISPR screensRNA sequencingmouse modelssingle-cell RNA sequencingWestern blotflow cytometrymolecular biology techniquesimmunological assays
Output against the department
Publications93bottom 22% of dept.315th of 402
this lab
most publishedleast published
Citations17ktop 26% of dept.106th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.