University of Nebraska Medical Center · PharmacologyNeuroimmune Dynamics Laboratory
Shilpa J Buch · Omaha, Nebraska
Research Focus
Dr. Shilpa J Buch's lab at the University of Nebraska Medical Center focuses on understanding how HIV and substance abuse like cocaine affect the brain. Their research investigates the role of immune cells in the brain, especially how these cells respond to HIV proteins and drugs, leading to inflammation and cognitive decline. By studying processes like ferritinophagy, they aim to develop new treatments to improve brain health for people living with HIV and addiction.
HIVneuroinflammationcocainemicrogliaextracellular RNAcognitive declineferritinophagydrug abuseneurocognition
Research Aims
5AIM 01Explore how HIV proteins disrupt ferritinophagy in microglia
AIM 02Test the effects of the drug C381 on restoring lysosomal function
AIM 03Investigate the interactions between HIV Tat and morphine in neuronal injury
AIM 04Develop RNA therapeutics to mitigate synaptic damage in NeuroHIV
AIM 05Validate findings using archival human and macaque brain samples.
Skills the Lab Values
in vivo mouse modelscell cultureRNA extractionflow cytometryWestern blotimmunohistochemistrymolecular cloningCRISPRbehavioral assays
Output against the department
Publications319top 24% of dept.112th of 462
this lab
most publishedleast published
Citations31ktop 8% of dept.39th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.