University of Texas Southwestern Medical Center · BiochemistryWnt Signaling and Cancer Therapeutics Lab
Chuo Chen · Dallas, Texas
Research Focus
Dr. Chuo Chen's lab at UT Southwestern Medical Center focuses on developing new drugs to treat cancer by targeting a specific cell signaling pathway known as Wnt/-catenin. This pathway is often dysfunctional in many cancers, particularly colorectal cancer, which affects thousands of people each year. The lab utilizes innovative chemical strategies and protein studies to understand how certain enzymes can control cancer growth and offer potential treatment solutions.
cancer therapyWnt pathwaycolorectal cancersmall-molecule drugstankyraseproteomicsin vivo studiesbiomarkersantineoplastic agents
Research Aims
5AIM 01Develop small-molecule drugs targeting Wnt/-catenin signaling.
AIM 02Investigate the role of tankyrases in cancer signaling pathways.
AIM 03Characterize the catalytic and scaffolding functions of tankyrases.
AIM 04Correlate genetic background with cancer cell response to treatment.
AIM 05Identify potential biomarkers for colorectal cancer therapies.
Skills the Lab Values
cell cultureproteomicsin vivo mouse modelsmass spectrometrysmall molecule synthesisdrug screening assaysWestern blottinggenetic profilingbioinformatics
Output against the department
Publications133bottom 38% of dept.250th of 402
this lab
most publishedleast published
Citations11ktop 45% of dept.182nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.