University of Pittsburgh-Pittsburgh Campus · NeuroscienceThathiah Lab
Amantha Thathiah · Pittsburgh, Pennsylvania
Research Focus
Dr. Amantha Thathiah's lab at the University of Pittsburgh focuses on understanding Alzheimer's disease, particularly how specific cell types in the brain react to the disease. They study a protein called GPR3, which might influence brain inflammation and cognitive decline in Alzheimer's patients. By investigating how GPR3 affects brain cells like microglia and neurons, the lab hopes to find new, safer treatments for Alzheimer's.
Alzheimer's DiseaseGPR3microgliaastrocytesneuroinflammationcognitionGPCR signalingdrug developmentcell signaling
Research Aims
3AIM 01Investigate how biased GPR3 signaling alters microglia activation and function in Alzheimer's disease models.
AIM 02Explore the effects of biased GPR3 signaling on the roles of astrocytes in Alzheimer's disease.
AIM 03Assess the impact of biased GPR3 signaling on neuronal function and cognitive outcomes in Alzheimer's disease.
Skills the Lab Values
cell culturein vitro experimentationanimal modelsbehavioral assaysmolecular biology techniquesCRISPR gene editingimmunohistochemistryRNA isolationWestern blotting
Output against the department
Publications74bottom 21% of dept.531st of 671
this lab
most publishedleast published
Citations3.8kbottom 28% of dept.480th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.