Baylor College of Medicine · GeneticsNakada Lab
Daisuke Nakada · Houston, Texas
Research Focus
Dr. Daisuke Nakada's lab focuses on studying hematopoietic stem cells (HSCs), which are essential for producing all blood cell types in the body. The research explores how HSCs react to stress, particularly in conditions like anemia, and seeks to uncover mechanisms that can enhance blood regeneration. By using advanced techniques such as lineage tracing and gene expression analysis, the lab aims to improve understanding of HSC behavior, which could lead to innovative treatments for anemia and other blood disorders.
hematopoietic stem cellserythroid differentiationanemiairon metabolismgene expressionTET2stem cell biologyregenerative medicinestress responselineage tracing
Research Aims
3AIM 01Investigate the heterogeneity of splenic hematopoietic stem cells during anemia.
AIM 02Examine the role of TET2 in promoting erythroid commitment of splenic HSCs.
AIM 03Investigate how TET2 protein is stabilized in HSCs during anemia.
Skills the Lab Values
Hematopoietic stem cell cultureLineage tracing techniquesGene expression analysisDNA demethylation assaysFlow cytometryIn vitro differentiation studiesIron chelation experimentsRNA sequencingProtein stabilization studiesMouse models of anemia
Output against the department
Publications125bottom 39% of dept.156th of 259
this lab
most publishedleast published
Citations6.9kbottom 37% of dept.164th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.