Temple University · Microbiology & ImmunologyNeutrophil Dynamics and Sepsis Unit
Laurie E Kilpatrick · Philadelphia, Pennsylvania
Research Focus
Dr. Laurie E Kilpatrick's lab focuses on understanding how different types of immune cells, specifically neutrophils, contribute to sepsis, a life-threatening condition caused by infection. The lab uses innovative techniques like 'organ-on-chip' technology to model human responses and characterize neutrophil behavior, aiming to develop targeted treatments for sepsis based on individual patient profiles. By linking immune cell characteristics to clinical outcomes, the research aims to improve therapies for this critical condition.
sepsisneutrophilsimmune responseorgan-on-chippersonalized medicineproteomicsvascular endotheliumtherapeuticsomicsmechanistic insights
Research Aims
3AIM 01Characterize the temporal progression of neutrophil functional phenotypes in patients with sepsis.
AIM 02Test how neutrophil functional phenotypes interact differentially with organ-specific endothelial cells.
AIM 03Determine the impact of sepsis patient phenotypes on response to available therapeutics.
Skills the Lab Values
cell cultureflow cytometryproteomicsmouse modelsin silico modelingdrug screeningbiological assaysimmunohistochemistryclinical data analysisBioinformatics
Output against the department
Publications129bottom 49% of dept.245th of 486
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.334th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.