SDSSouth Dakota State University · Pharmacology
The NeuroShield Lab
Jagdish Singh · Brookings, South Dakota
Research Focus
Dr. Jagdish Singh's lab focuses on developing new therapies for Alzheimer's Disease, a common neurodegenerative disorder. The lab is particularly interested in using gene therapy to increase levels of certain proteins, like APOE2 and VGF, that may protect brain function and improve cognitive abilities. They create specialized nanoparticles to deliver these therapeutic genes across the blood-brain barrier, aiming to enhance the effectiveness of treatments for Alzheimer's and related conditions.
Alzheimer's Diseasegene therapyAPOE2VGFblood-brain barriernanoparticlesneurodegenerationcognitive functionliposomal delivery
Research Aims
3AIM 01Design liposomal nanoparticles for targeted gene delivery to the brain.
AIM 02Evaluate the safety and effectiveness of gene therapy in mouse models of Alzheimer's Disease.
AIM 03Investigate the impact of APOE2 gene therapy on cognitive decline and neurodegeneration.
Skills the Lab Values
gene delivery techniquesnanoparticle synthesisin vitro cell cultureanimal modelingliposome characterizationPCRWestern blottingmicrodialysis techniquesflow cytometry
Output against the department
Publications245top 33% of dept.153rd of 462
this lab
most publishedleast published
Citations9.0ktop 42% of dept.195th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.