Oregon State University · BiochemistryThe BioCode Lab
Ryan A Mehl · Corvallis, Oregon
Research Focus
Dr. Ryan A. Mehl's lab at Oregon State University focuses on advancing Genetic Code Expansion (GCE) technology to enhance biomedical research. The lab aims to make the engineering of proteins with non-canonical amino acids more accessible to a wider range of researchers, creating powerful tools for investigating diseases and developing new therapeutics. Through training and community engagement, the lab will ensure that these methods are widely adopted in the scientific community.
Genetic Code Expansionprotein engineeringnon-canonical amino acidsbiomedical toolsprotein functiondisease mechanismsbiotherapeutics
Research Aims
5AIM 01Develop user-friendly methods for incorporating non-canonical amino acids into proteins.
AIM 02Enhance protein production efficiency in E. coli and mammalian cells.
AIM 03Create stable cell lines for reproducible research.
AIM 04Provide extensive training and resources for researchers using GCE technology.
AIM 05Facilitate collaboration and community support among GCE users.
Skills the Lab Values
protein expressioncell cultureEscherichia coli manipulationmammalian cell line developmentbioorthogonal ligationWestern blottingimmunofluorescence microscopyprotocol optimizationdata sharing platformsworkshop facilitation
Output against the department
Publications197top 42% of dept.168th of 402
this lab
most publishedleast published
Citations6.7kbottom 37% of dept.254th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.