University of Colorado Boulder · BiochemistryMembrane Protein Dynamics Lab
Jingshi Shen · Boulder, Colorado
Research Focus
Dr. Jingshi Shen's lab at the University of Colorado studies how cells regulate the movement of proteins within their membranes, which is essential for proper metabolic function. They specifically focus on how vesicle fusion—a process where small membrane-bound packages merge with larger membranes—affects glucose transport and insulin response in human cells. Research in this lab aims to uncover the underlying mechanisms of metabolic disorders like insulin resistance and type 2 diabetes, which could ultimately lead to new treatment strategies.
vesicle fusioninsulin resistancemetabolismGLUT4type 2 diabetesprotein traffickingregulated secretionCRISPRadipocyteslipid composition
Research Aims
5AIM 01Investigate how proteins interact during the vesicle fusion process.
AIM 02Identify new proteins involved in GLUT4 translocation in adipocytes.
AIM 03Clarify the effects of lipid composition on vesicle fusion kinetics.
AIM 04Examine the impact of a high-fat diet on insulin resistance in mouse models.
AIM 05Explore therapeutic targets for treating metabolic disorders.
Skills the Lab Values
CRISPRcell culturemouse modelsbiochemical assaysbiophysical assaysgenetic modificationflow cytometrymolecular cloninghuman pluripotent stem cell differentiation
Output against the department
Publications88bottom 20% of dept.319th of 402
this lab
most publishedleast published
Citations5.0kbottom 29% of dept.287th of 402
this lab
most citedleast cited
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