Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyCytomegalovirus Therapeutics Group
Domenico Tortorella · New York, New York
Research Focus
Domenico Tortorella's lab at the Icahn School of Medicine focuses on developing new antiviral treatments for human cytomegalovirus (CMV), a common virus that can cause severe illness in newborns and immunocompromised patients. The research aims to identify and create compounds that can inhibit the early stages of CMV infection, potentially preventing its spread and reducing the associated health risks for vulnerable populations. This work is crucial as existing treatments often lead to drug resistance and severe side effects.
cytomegalovirusantiviral agentsviral replicationdrug resistancetherapeutics development
Research Aims
4AIM 01Characterize the mechanism of action of NAPA compounds.
AIM 02Optimize NAPA compounds through SAR-driven analog generation.
AIM 03Evaluate NAPA compounds to limit virus proliferation using in vitro models.
AIM 04Assess pharmacokinetics and efficacy of prioritized NAPA analogs in vivo.
Skills the Lab Values
high-content screeningin vitro modelsstructure-activity relationshippharmacokineticsdrug optimizationcell culturecompound screeningmolecular biology techniquesanalysis of viral loadtoxicity assessment
Output against the department
Publications114bottom 43% of dept.276th of 486
this lab
most publishedleast published
Citations6.7kbottom 48% of dept.253rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.