University of California-San Francisco · NeuroscienceHauser Lab
Stephen L Hauser · San Francisco, California
Research Focus
Dr. Stephen L. Hauser's lab at UCSF focuses on understanding the role of B cells in multiple sclerosis (MS), a debilitating autoimmune disease of the central nervous system. The team investigates how B cells contribute to the onset and progression of MS by studying samples from patients at different stages of the disease. They combine advanced imaging techniques, genetic analysis, and innovative antibody technologies to uncover the mechanisms that trigger MS and influence its progression, aiming to improve therapeutic strategies for patients.
multiple sclerosisB cellsautoimmune diseaseCNS diseasesbiobankingantibody screeningneuroimagingsingle cell transcriptomicsdisease progression
Research Aims
5AIM 01Identify triggers of multiple sclerosis using advanced imaging and genetic techniques.
AIM 02Characterize the molecular diversity of B cells in patients with varying stages of MS.
AIM 03Investigate the role of antibodies in mediating disease progression in MS.
AIM 04Screen for pathogenic B cell populations in patient samples using antibody fingerprinting.
AIM 05Develop new therapeutic strategies based on understanding B cell dynamics in MS.
Skills the Lab Values
PCRcell culturehigh-field MRIgenetic analysissingle cell transcriptomicsantibody library creationphage displaydata analysisclinical cohort studies
Output against the department
Publications482top 12% of dept.82nd of 671
this lab
most publishedleast published
Citations34ktop 11% of dept.71st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.