University of Texas Southwestern Medical Center · BiologyThe Mucus Lab
Jeffrey Sorelle · Dallas, Texas
Research Focus
Dr. Jeffrey Sorelle's lab at UT Southwestern Medical Center focuses on understanding disorders related to glycosylation, specifically those that affect the intestines. The team uses a special mouse model to study how defects in the production of specific sugars impact gut health and functionality, which is particularly relevant for patients with a condition called MPI deficiency. By exploring how these sugars affect the function of mucus in the intestines, the lab aims to develop new therapeutic strategies for gastrointestinal disorders.
glycosylationintestinal healthmouse modelsmucinstherapeutic interventionsgastrointestinal disordersprotein modificationbarrier functionsugar therapy
Research Aims
3AIM 01Investigate the role of N-glycosylation in goblet cell survival and mucus production.
AIM 02Understand how N-glycosylation affects Muc2 folding and dimerization.
AIM 03Explore the mechanisms by which mannose therapy protects gastrointestinal barriers.
Skills the Lab Values
mouse modelsN-glycosylation analysismucosal barrier assessmentconditional knockout techniquesgoblet cell cultureinflammation assaysmucins characterizationpre-clinical testingbiochemical assays
Output against the department
Publications95bottom 33% of dept.692nd of 1,033
this lab
most publishedleast published
Citations1.7kbottom 11% of dept.919th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.