University of Pittsburgh-Pittsburgh Campus · PharmacologyLiver Regeneration Research Lab
Michael Oertel · Pittsburgh, Pennsylvania
Research Focus
Dr. Michael Oertel's lab at the University of Pittsburgh focuses on understanding and improving liver health by studying cell competition, a process where certain cells outcompete others for space and resources. Their research aims to use this knowledge to develop new cell-based therapies that can help treat chronic liver diseases. By investigating how fetal liver cells behave differently compared to mature liver cells, the lab seeks to produce enhanced liver progenitor cells that can effectively regenerate damaged tissue.
cell competitionliver diseasescell transplantationstem cellsfibrosishepatocytetherapeutic strategiesstem cell therapyliver organoids
Research Aims
5AIM 01Investigate the mechanisms of cell competition in the liver.
AIM 02Develop methods to enhance liver cell regeneration using fetal liver characteristics.
AIM 03Analyze the effects of blocking activin A signaling on liver repair and transplantation.
AIM 04Create liver progenitor cells from human fetal liver organoids for therapeutic use.
AIM 05Explore new therapeutic strategies for chronic liver disease treatment.
Skills the Lab Values
cell cultureanimal modelsliver transplantation studiesin vivo experimentationmolecular profilingsmall-molecule signaling inhibitioninduced pluripotent stem cellsorganoid technologydata analysis
Output against the department
Publications231top 35% of dept.164th of 462
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.327th of 462
this lab
most citedleast cited
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