Ohio State University-Main Campus · Biomedical EngineeringGuo Glioblastoma Lab
Deliang Guo · Columbus, Ohio
Research Focus
Dr. Deliang Guo's lab at Ohio State University focuses on finding new treatment strategies for glioblastoma (GBM), an aggressive brain tumor. The research explores how GBM cells utilize lipids and glutamine for growth and survival, aiming to disrupt these processes to develop effective therapies. By studying lipid metabolism and testing new drug combinations, the lab hopes to identify safer and more effective ways to treat this challenging disease.
glioblastomalipid metabolismglutaminedrug therapytumor growthlysosomal functionlipid dropletscholesterol homeostasisautophagy
Research Aims
4AIM 01Investigate how glioblastoma cells upregulate glutamine uptake and lipogenesis when lysosome function is inhibited.
AIM 02Validate the effectiveness of combining lysosomal function inhibitors with therapies targeting glutamine metabolism and lipogenesis in glioblastoma models.
AIM 03Examine the role of lipid droplets in maintaining cholesterol homeostasis and mitochondrial function in glioblastoma cells.
AIM 04Develop novel treatment strategies by disrupting lipid storage and metabolism pathways in glioblastoma.
Skills the Lab Values
cell culturedrug screeningin vivo mouse modelsWestern blotRNA sequencingflow cytometrymicroscopymetabolic assaysgenetic manipulation
Output against the department
Publications167bottom 37% of dept.371st of 595
this lab
most publishedleast published
Citations8.2ktop 41% of dept.246th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.