University of Southern California · PhysiologyThe NeuroRejuvenation Lab
Michael Bonaguidi · Los Angeles, California
Research Focus
Dr. Michael Bonaguidi's lab focuses on understanding how aging affects neural stem cells (NSCs), which are crucial for brain health and memory. They investigate ways to rejuvenate these cells to improve cognitive function, especially in the context of aging and Alzheimer's disease. The lab combines advanced techniques like pharmacogenomics and computational biology to uncover the mechanisms behind NSC aging and neurogenesis, aiming to develop therapeutic strategies for age-related cognitive decline.
neural stem cellsagingAlzheimer's diseasecognitionpharmacogenomicsneurogenesisregenerative medicinesingle cell transcriptomicscomputational biology
Research Aims
3AIM 01Identify mechanisms that reverse aging in neural stem cells.
AIM 02Augment the function of older neural stem cells.
AIM 03Sustain the rejuvenation effects in neural stem cells.
Skills the Lab Values
single cell transcriptomicscomputational network analysispharmacogenomicsanimal behavioral studiesstem cell culturedata integrationmolecular biology techniquesbioinformaticssystems biology
Output against the department
Publications66bottom 13% of dept.249th of 286
this lab
most publishedleast published
Citations5.0kbottom 43% of dept.163rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.