Stanford University · GeneticsEngreitz Lab
Jesse M Engreitz · Stanford, California
Research Focus
Dr. Jesse M. Engreitz's lab at Stanford University focuses on understanding how DNA regulatory sequences control gene expression, particularly in the context of diseases like Alagille Syndrome. Through innovative techniques like CRISPR and high-throughput screening, the lab aims to develop genetic tools that can correct gene expression patterns in human cells. This research not only seeks to provide insights into gene regulation but also aims to offer new therapeutic approaches for genetic disorders.
Alagille Syndromegene regulationCRISPRenhancer mappinggene therapytranscription factorsgenome engineeringhuman pluripotent stem cellsgenetic variantsdisease mechanisms
Research Aims
5AIM 01Map the regulatory DNA elements that influence gene expression in specific cell types.
AIM 02Engineer the JAG1 gene promoter to enhance its expression for potential gene therapy in Alagille Syndrome.
AIM 03Develop predictive models to link genetic variants to their regulatory functions across different cell types.
AIM 04Characterize enhancer-gene regulatory interactions using single-cell multiomic datasets.
AIM 05Investigate how genetic variations affect risks related to cardiovascular diseases.
Skills the Lab Values
CRISPRgene editinghigh-throughput screeningcell culturegenome mappingcomputational modelingRNA sequencingfluorescent in situ hybridizationmouse modelsbioinformatics
Output against the department
Publications1bottom 1% of dept.258th of 259
this lab
most publishedleast published
Citations0bottom 1% of dept.258th of 259
this lab
most citedleast cited
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