University of North Carolina at Chapel Hill · BiochemistryMarzluff Cytoplasmic Lab
William F. Marzluff · Chapel Hill, North Carolina
Research Focus
Dr. William F. Marzluff's lab at the University of North Carolina Chapel Hill focuses on understanding the tumor suppressor protein p53, especially its function outside the nucleus. The lab investigates how p53 can regulate important cellular processes like apoptosis and autophagy in the cytoplasm. By studying mutant forms of p53 modeled after bat genetics, the team aims to uncover novel regulatory mechanisms that could influence cancer treatment and aging.
p53tumor suppressorautophagyapoptosislipid metabolismK63-linked ubiquitinationbat geneticsin vivo modelscellular regulationtherapeutic strategies
Research Aims
5AIM 01Investigate the cytoplasmic functions of p53 in regulating apoptosis and autophagy.
AIM 02Examine the role of CUL9 in modulating p53 activity through K63-linked ubiquitination.
AIM 03Explore the metabolic impacts of cytoplasmic p53 on glycolysis and lipogenesis.
AIM 04Understand how altered nuclear localization signals in p53 affect its function in bats.
AIM 05Develop therapeutic strategies based on the insights gained from p53 regulation in cancer and aging.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysmass spectrometrygenomic analysisprotein interaction studiesprotein purificationWestern blotRT-PCRCRISPR
Output against the department
Publications341top 17% of dept.68th of 402
this lab
most publishedleast published
Citations21ktop 20% of dept.79th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.