University of California-San Diego · BiologyJin Lab
Yishi Jin · La Jolla, California
Research Focus
Dr. Yishi Jin's research lab focuses on understanding how synapses and axons develop and maintain their functions throughout the life of an organism. Using the tiny worm C. elegans, the lab investigates the complexities of nerve connections to gain insights into the molecular mechanisms that govern nerve function and repair. This research is crucial for identifying how disruptions can lead to neurological disorders, offering hope for better treatments and understanding of such conditions.
axon developmentsynapse maintenanceC. elegansaxon regenerationneural circuitsgene discoveryprotein phase separationcell signalingtranscriptional regulation
Research Aims
5AIM 01Elucidate the mechanisms underlying synapse development and maintenance.
AIM 02Investigate axon regeneration and the genetic factors involved.
AIM 03Examine the role of neuronal activity in spatial and temporal regulation of synaptic connections.
AIM 04Explore the impact of protein phase separation on cellular processes.
AIM 05Cross-examine the conservation of mechanisms between C. elegans and mammalian systems.
Skills the Lab Values
in vivo imagingsingle-cell RNA sequencinggenetic screeningcalcium imagingC. elegans handlingmolecular genetics techniquesdata analysisexperimental designneuron culture
Output against the department
Publications246top 24% of dept.253rd of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.281st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.