Santa Clara University · EngineeringExosome Therapeutics Lab
Biao Lu · Santa Clara, California
Research Focus
Dr. Biao Lu's lab focuses on developing innovative nanomedicines to combat Alzheimer's disease through targeted removal of toxic proteins. They utilize exosomes, which are tiny vesicles that cells use for communication, to specifically target and break down amyloid-beta proteins that are known to accumulate in the brains of Alzheimer's patients. The research aims to improve current treatment options and offers potential solutions for other amyloid-related disorders.
Alzheimer's diseaseamyloid-betaexosomesnanomedicinetherapeutic strategiesgenetic engineeringprotein targeting
Research Aims
3AIM 01Develop genetic strategies to load amyloid-beta targeting antibodies and degrading enzymes onto exosomes.
AIM 02Establish procedures for the isolation and characterization of exosomes.
AIM 03Produce and evaluate therapeutic quality exosomes from selected source cells for amyloid degradation.
Skills the Lab Values
genetic engineeringexosome isolation and characterizationcell culturemolecular imagingbiochemical assayscellular assaysprotein purificationnanoparticle productionfluorescence resonance energy transfer (FRET)
Output against the department
Publications84bottom 17% of dept.229th of 278
this lab
most publishedleast published
Citations2.3kbottom 17% of dept.231st of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.