MCWMedical College of Wisconsin · Biophysics
Pediatric Brain Tumor Therapeutics Lab
Mona M Al-Gizawiy · Milwaukee, Wisconsin
Research Focus
Dr. Mona Al-Gizawiy's lab focuses on developing new treatments for aggressive pediatric brain tumors, specifically pediatric high-grade gliomas and atypical teratoid rhabdoid tumors. By exploring the use of gallium maltolate, a special metallocompound that mimics iron, the lab aims to inhibit tumor growth and improve survival rates for affected children while minimizing side effects. The research not only targets the cancer itself but also considers the overall quality of life of the patients.
pediatric brain tumorsgallium maltolateiron metabolismhigh-grade gliomastumor therapy
Research Aims
5AIM 01Investigate the effect of gallium maltolate on pediatric high-grade gliomas and ATRT cells.
AIM 02Develop a tissue sensitivity profile using advanced imaging and bioenergetics techniques.
AIM 03Explore the combination of gallium maltolate with radiation therapy to enhance therapeutic effects.
AIM 04Assess the impact of gallium maltolate on survival and quality of life in pediatric brain tumor patients.
AIM 05Understand the mechanisms behind the efficacy of gallium maltolate treatment in brain tumors.
Skills the Lab Values
cell culturein vitro assaysanimal modelsMRI-guided biopsyinductively coupled plasma mass spectrometry
Output against the department
Publications46bottom 1% of dept.10th of 10
this lab
most publishedleast published
Citations524bottom 1% of dept.10th of 10
this lab
most citedleast cited
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