University of Toledo · PhysiologyGut Microbiota and Hypertension Lab
Bina Joe · Toledo, Ohio
Research Focus
Dr. Bina Joe's lab at the University of Toledo focuses on understanding the role of gut microbiota in hypertension, a leading cause of cardiovascular disease. The lab investigates how specific gut bacteria influence the levels of conjugated bile acids, which may have protective effects against high blood pressure. By using advanced rodent models, the team aims to uncover the biochemical mechanisms involved and explore new therapeutic approaches to lower hypertension through dietary interventions.
hypertensiongut microbiotabile acidscardiovascular diseasemetabolomicsanimal modelsceramidemicrobiomenutritional reprogrammingtherapeutic strategies
Research Aims
5AIM 01Investigate why conjugated bile acids are depleted in individuals with hypertension.
AIM 02Identify the specific gut microbiota responsible for depleting conjugated bile acids.
AIM 03Explore how taurocholic acid functions in lowering hypertension through the FXR-ceramide pathway.
AIM 04Develop novel animal models to study the interactions between gut microbiota and bile acid biochemistry.
AIM 05Propose dietary strategies to enhance levels of conjugated bile acids as a potential therapeutic approach to manage hypertension.
Skills the Lab Values
animal husbandrymicrobiota analysismetabolomicsgenetic modelsCRISPR/Cas technologybiochemical assaysblood pressure monitoringWestern blotmolecular biology techniquesspectrometry
Output against the department
Publications324top 14% of dept.40th of 286
this lab
most publishedleast published
Citations8.6ktop 39% of dept.111th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.