EUEmory University · Genetics
Zhao Transdifferentiation Lab
Changsheng Zhao · Atlanta, Georgia
Research Focus
Dr. Changsheng Zhao's lab at Emory University focuses on understanding how prostate cancer cells change their identity from luminal cells to neuroendocrine cells, a transition that is key to the progression of a lethal form of prostate cancer. By investigating the molecular mechanisms behind this transformation, the lab aims to identify new drug targets and biomarkers that could help in diagnosing and treating advanced prostate cancer. The lab employs innovative models and advanced genomic techniques to map these cellular changes over time.
prostate cancerneuroendocrine transdifferentiationepigenetic mechanismsbiomarker identificationchromatin remodeling
Research Aims
3AIM 01Investigate the role of NKX2-1 in FOXA2-driven neuroendocrine transdifferentiation.
AIM 02Evaluate the requirement of TET1 induction for regional DNA demethylation in transdifferentiation.
AIM 03Validate genomic and epigenomic reprogramming in clinical prostate cancer samples.
Skills the Lab Values
RNA sequencingDNA methylation analysischromatin immunoprecipitation3D chromatin architecture analysiscell culture
Output against the department
Publications455top 15% of dept.39th of 259
this lab
most publishedleast published
Citations19ktop 30% of dept.78th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.