University of Washington-Seattle Campus · Mathematics & StatisticsGenomic Insight Lab
Sara Mostafavi · Seattle, Washington
Research Focus
Dr. Sara Mostafavi's lab at the University of Washington focuses on using advanced computational models to understand how genetic variations influence gene expression and contribute to complex diseases like autism spectrum disorder and schizophrenia. By integrating diverse genomic data, the lab works to develop tools that can predict functional outcomes from personal genomes, helping to uncover the biological processes behind these conditions and potentially leading to personalized therapeutic strategies.
gene regulationgenetic variationdeep learningautism spectrum disorderschizophreniafunctional genomicspredictive modelingcomputational biologypersonalized medicine
Research Aims
3AIM 01Develop S2F models that predict gene expression consequences of natural genetic variations.
AIM 02Create modularized model architectures to enhance adaptability in data-limited scenarios.
AIM 03Apply enhanced models to investigate regulatory mechanisms in neurodevelopmental diseases like ASD and SCZ.
Skills the Lab Values
computational modelingdeep learning techniqueswhole-genome sequencingdata analysisbiological data integrationmachine learningATAC-seqgene expression analysisbioinformatics
Output against the department
Publications226top 50% of dept.65th of 131
this lab
most publishedleast published
Citations35ktop 16% of dept.21st of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.