Johns Hopkins University · BiochemistryNeurodegenerative Disease Mechanisms Lab
Jiou Wang · Baltimore, Maryland
Research Focus
Dr. Jiou Wang's lab at Johns Hopkins University focuses on understanding the underlying causes of neurodegenerative diseases like ALS and frontotemporal dementia (FTD). They investigate how genetic factors, particularly a mutation in the C9orf72 gene, lead to neuronal damage. The lab employs a combination of biochemical, molecular, and genetic techniques to explore how these mutations disrupt protein and RNA functions, contributing to neurodegeneration. Ultimately, their goal is to find new avenues for treatment and intervention for these serious neurological conditions.
C9orf72ALSfrontotemporal dementiaRNA-binding proteinsstress granulesneurodegenerationprotein homeostasisgenetic mechanismsdisease pathwaysneurobiology
Research Aims
5AIM 01Investigate the novel disease pathways associated with C9orf72-linked ALS/FTD.
AIM 02Understand the molecular mechanisms of stress-related ribonucleoprotein granules.
AIM 03Identify the pathogenic cascades initiated by C9orf72 hexanucleotide repeat expansion.
AIM 04Characterize protein and RNA homeostasis under stress conditions.
AIM 05Uncover novel functions of disease-associated RNA-binding proteins.
Skills the Lab Values
PCRcell culturemouse modelsWestern blotRNA sequencingbiochemical assaysgenetic engineeringmicroscopybioinformaticsmolecular cloning
Output against the department
Publications41bottom 5% of dept.380th of 402
this lab
most publishedleast published
Citations5.6kbottom 32% of dept.271st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.