Case Western Reserve University · Biomedical EngineeringThe Nanovaccine Initiative
Zheng-Rong Lu · Cleveland, Ohio
Research Focus
Dr. Zheng-Rong Lu's lab focuses on creating advanced anticancer therapies specifically targeting pancreatic cancer. The team is developing innovative nanovaccines made from lipid nanoparticles that aim to enhance immunotherapy effectiveness against this aggressive cancer. By combining these nanovaccines with immune checkpoint inhibitors, the research seeks to significantly improve treatment outcomes for patients with pancreatic ductal adenocarcinoma, a disease known for its low survival rates.
nanovaccinespancreatic cancerimmunotherapyoncogenesmagnetic resonance imaging
Research Aims
3AIM 01Develop multifunctional ionizable lipid nanoparticles for cancer vaccines.
AIM 02Evaluate the effectiveness of the nanovaccines in mouse models.
AIM 03Investigate combination therapy of nanovaccines with immune checkpoint inhibition.
Skills the Lab Values
nanoparticle formulationimmunology techniquesmouse model experimentsmagnetic resonance imaging (MRI)cancer vaccine development
Output against the department
Publications304top 31% of dept.182nd of 595
this lab
most publishedleast published
Citations8.8ktop 39% of dept.231st of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.