University of Pennsylvania · GeneticsThe Genomic Harmony Lab
Golnaz Vahedi · Philadelphia, Pennsylvania
Research Focus
Dr. Golnaz Vahedi's lab at the University of Pennsylvania investigates how the three-dimensional structure of our genome affects immune cell functions and plays a role in allergic disorders. By specifically looking at T cells, her research aims to uncover the connections between genomic architecture and diseases like asthma and dermatitis, aiming for a better understanding of the genetic factors driving these conditions. The lab uses genetically modified mouse models and advanced genomic techniques to explore these relationships.
3D genome organizationCD4+ T cellsallergic responsesgenomic architecturegene regulation
Research Aims
4AIM 01Investigate how 3D genome folding affects T cell function in allergic disorders.
AIM 02Determine the role of genetic variations in T cell responses to allergens.
AIM 03Develop genetically modified mouse models to study immune responses.
AIM 04Analyze the interactions between regulatory elements and target genes in immune cells.
Skills the Lab Values
gene editingmouse modelsflow cytometrychromatin analysisT cell culture
Output against the department
Publications113bottom 36% of dept.164th of 259
this lab
most publishedleast published
Citations10ktop 49% of dept.126th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.