University of Michigan-Ann Arbor · Biomedical EngineeringOvarian Renewal Research Unit
Ariella Shikanov · Ann Arbor, Michigan
Research Focus
Dr. Ariella Shikanov's lab focuses on developing innovative therapies to restore ovarian function in young women who suffer premature ovarian insufficiency, often due to cancer treatments. The research aims to enhance the delivery of cell-based therapies using immunoisolating capsules to prevent immune rejection. This work seeks to test the efficacy of these therapies in non-human primate models, paving the way for future clinical applications.
ovarian functionpremature ovarian insufficiencyimmunoisolationcell-based therapynon-human primates
Research Aims
5AIM 01Develop immunoisolating capsules to enhance cell therapy for ovarian restoration.
AIM 02Test the efficacy of encapsulated ovarian allografts in adolescent non-human primates.
AIM 03Investigate the immune response to repeated ovarian graft implantations.
AIM 04Evaluate the quality of oocytes produced in capsule-enclosed grafts.
AIM 05Assess the longevity of reproductive functions restored by the therapy.
Skills the Lab Values
hydrogel fabricationanimal model experimentationimmunoassayscell culture techniqueshormone analysissurgical implantation techniquesflow cytometryRNA extractionPCRdata analysis
Output against the department
Publications156bottom 34% of dept.393rd of 595
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.389th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.