Columbia University in the City of New York · PhysiologyColecraft Lab
Henry M. Colecraft · New York, New York
Research Focus
Dr. Henry M. Colecraft's lab focuses on understanding the role of a specific calcium channel gene (CACNA1A) in various neurological disorders. The research aims to develop innovative therapies by examining how different mutations in this gene lead to conditions like migraines, epilepsy, and ataxia. The lab combines molecular biology, biophysics, and advanced neuroscience techniques to create potential treatments tailored to these mutations.
CACNA1Aneurological disordersgene therapycalcium channelsepilepsymigraineataxiabiophysics
Research Aims
3AIM 01Investigate the functional impact of various CACNA1A mutations on calcium channels.
AIM 02Develop human patient-derived neurons to model CACNA1A disorders and test new therapeutic molecules.
AIM 03Evaluate disease mechanisms and potential treatments using mouse models.
Skills the Lab Values
electrophysiologycell cultureCRISPR/Cas technologymouse modelshuman induced pluripotent stem cell (hiPSC) techniquesimmunofluorescenceflow cytometrymolecular cloningdata analysis
Output against the department
Publications166top 44% of dept.124th of 286
this lab
most publishedleast published
Citations5.0kbottom 43% of dept.164th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.