Thomas Jefferson University · BiologyCalcium Dynamics Laboratory
Gyorgy Hajnoczky · Philadelphia, Pennsylvania
Research Focus
Dr. Gyorgy Hajnoczky's lab focuses on understanding how changes in calcium levels within mitochondria affect neuronal health. They explore the role of specific proteins, particularly the MICU family, in calcium signaling and how their dysfunction can lead to neurological disorders. By using advanced imaging techniques and mouse models, the lab aims to determine the connections between mitochondrial calcium homeostasis, neurodegeneration, and brain functioning in different conditions, such as hypoxia and developmental stages.
mitochondrial calciumneuronal healthMICU proteinsneurodegenerationhypoxia
Research Aims
4AIM 01Investigate how neuronal loss of MICU1, MICU2, or MICU3 affects calcium signaling and synaptic release.
AIM 02Examine the impact of these MICU losses on mitochondrial oxidant production and resultant cell injury.
AIM 03Explore the dynamic changes in MICU isoforms during neuronal development and its effects on brain function.
AIM 04Assess if ischemia-reperfusion injuries lead to alterations in MICU1 turnover and mitochondrial damage.
Skills the Lab Values
PCRmouse modelsfunctional imaging3D electron microscopycell culturebiochemistryfluorescence imagingcalcium signaling techniquesgenetic manipulation of miceanimal behavior assessments
Output against the department
Publications258top 23% of dept.239th of 1,033
this lab
most publishedleast published
Citations31ktop 10% of dept.107th of 1,033
this lab
most citedleast cited
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