University of Alabama at Birmingham · NeuroscienceKing Neuroinflammation Lab
Peter H King · Birmingham, Alabama
Research Focus
Dr. Peter H. King’s lab focuses on understanding and potentially treating inflammation caused by ischemic strokes, which are a significant cause of death and disability. The team investigates a molecule called HuR that plays a role in promoting inflammation in the brain after a stroke. By inhibiting HuR, they aim to reduce inflammation and enhance neuroprotection to improve recovery outcomes for stroke patients, ultimately contributing to better management of strokes and related neurological diseases.
ischemic strokeneuroinflammationHuR inhibitionCNSneuroprotectionmicrogliaastrocytesacute injurybrain healthcytokines
Research Aims
3AIM 01Characterize the beneficial effects of HuR inhibition using the small molecule SRI-42127 after ischemic stroke.
AIM 02Assess the mechanisms by which HuR inhibition improves recovery following an ischemic stroke.
AIM 03Investigate the roles of glial and macrophage HuR in driving neuroinflammation and contributing to secondary injury after ischemic stroke.
Skills the Lab Values
cell cultureanimal models (mice)RNA extraction and analysisimmunohistochemistryflow cytometrydrug administration techniquesmolecular biology techniquesbehavioral testing in animalsWestern blottingdata analysis using statistical software
Output against the department
Publications177top 42% of dept.284th of 671
this lab
most publishedleast published
Citations7.5ktop 49% of dept.332nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.