Yale University · NeuroscienceCenter for Immune System Research
David A. Hafler · New Haven, Connecticut
Research Focus
David A. Hafler's research lab at Yale University focuses on understanding the immune system, particularly how T cells function in the context of autoimmune diseases and cancers like glioblastoma. They explore the roles of co-inhibitory pathways, especially TIGIT and PD-1, in regulating immune responses, aiming to develop innovative therapies to treat diseases caused by immune system dysfunction. The lab conducts both basic and translational research, integrating animal models and clinical trials to advance our understanding of immune mechanisms and identify new treatment strategies.
autoimmunityT cell dysfunctionglioblastomaimmunotherapyimmune checkpointsTIGITPD-1cancercentral nervous system diseasesinflammation
Research Aims
4AIM 01Investigate the mechanisms of T cell dysfunction in autoimmune diseases and cancer.
AIM 02Evaluate the therapeutic potential of targeting TIGIT and PD-1 pathways.
AIM 03Examine the interactions between immune and tumor microenvironments in glioblastoma.
AIM 04Develop novel immunotherapeutic strategies for treating glioblastoma and autoimmune diseases.
Skills the Lab Values
cell cultureflow cytometrymouse modelsclinical trial designmultiplexed immunofluorescencesingle-cell RNA sequencingmolecular biology techniquesimmunohistochemistrybioinformaticsdata analysis
Output against the department
Publications713top 7% of dept.45th of 671
this lab
most publishedleast published
Citations76ktop 3% of dept.22nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.