Thomas Jefferson University · NeuroscienceNeurodegeneration and Genomic Stability Lab
Davide Trotti · Philadelphia, Pennsylvania
Research Focus
Dr. Davide Trotti's research lab at Thomas Jefferson University focuses on understanding the biological mechanisms behind neurodegenerative diseases, particularly C9orf72-associated ALS and frontotemporal dementia. The lab investigates how genomic instability and the mobilization of transposable elements can lead to neuronal damage and cell death. They also explore potential therapeutic strategies to intervene in these processes and improve outcomes for affected patients.
neurodegenerative diseasesC9orf72ALSfrontotemporal dementianeuroinflammationgenomic instabilitytransposable elementscGAS-STING pathwayapoptosis
Research Aims
3AIM 01Identify patterns of transposon mobilization in C9-ALS/FTD using brain organoids derived from patient iPSC lines.
AIM 02Elucidate the activation of the c-JUN/TE/cGAS/STING pathway in C9-ALS/FTD by studying patient-derived iPSC lines and post-mortem CNS tissues.
AIM 03Explore therapeutic potential by inhibiting the c-JUN/TE/cGAS/STING pathway in C9-ALS/FTD organoids.
Skills the Lab Values
ATAC-seqbrain organoid generationiPSC cultureRNA-DNA hybrid analysischromatin profilingsmall molecule drug screeningcellular imaging techniquespathway inhibition strategiesneural cell line modeling
Output against the department
Publications115bottom 40% of dept.400th of 671
this lab
most publishedleast published
Citations8.1ktop 47% of dept.313th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.