University of Utah · NeuroscienceRNA Dynamics and Neurodevelopment Lab
Nichole L Link · Salt Lake City, Utah
Research Focus
Dr. Nichole L Link's lab focuses on understanding how certain RNA-binding proteins influence brain development and are connected to neurodevelopmental disorders like autism. They investigate the role of these proteins in stabilizing important mRNA molecules in neurons, which is crucial for proper brain formation. The lab uses advanced genetic models, including fruit flies and mouse cultures, to study these mechanisms and their implications for human diseases.
RNA binding proteinsautism spectrum disorderbrain developmentgenetic modelingneurodevelopmental disordersmRNA stabilityDrosophilacell culturemouse modelsmolecular mechanisms
Research Aims
5AIM 01Investigate the role of IGF2BP3 in neuronal development.
AIM 02Study mRNA stability of Sap47 in neurons.
AIM 03Determine the effects of RNA-binding proteins on neuron morphology.
AIM 04Explore genetic variants associated with neurodevelopmental disorders.
AIM 05Examine the role of Sap47 in brain development.
Skills the Lab Values
RNA isolationmRNA stability assayscell culture techniquesDrosophila genetic manipulationmouse hippocampal culturesimmunoprecipitationphenotype analysisWestern blotin vivo pulse-chase assaysbiochemical analysis
Output against the department
Publications32bottom 6% of dept.632nd of 671
this lab
most publishedleast published
Citations1.4kbottom 8% of dept.614th of 671
this lab
most citedleast cited
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