University of California-Irvine · Biomedical EngineeringCardiovascular Health and Sleep Apnea Research Unit
Anna Grosberg · Irvine, California
Research Focus
Dr. Anna Grosberg's lab at UC Irvine focuses on understanding how obstructive sleep apnea (OSA) affects heart and blood vessel health. By combining clinical data with advanced tissue engineering techniques, the lab aims to explore the mechanisms linking OSA to cardiovascular diseases. This research seeks to develop better diagnostic tools and treatment strategies for patients suffering from OSA and associated cardiovascular complications.
obstructive sleep apneacardiovascular diseasestissue engineeringmathematical modelinghypoxia
Research Aims
5AIM 01Investigate the relationship between obstructive sleep apnea and cardiovascular disease.
AIM 02Develop a mathematical model to quantify hypoxia in OSA patients.
AIM 03Optimize in vitro models to study the effects of intermittent hypoxia on the microvasculature.
AIM 04Employ a heart-on-a-chip model to examine cardiac impacts of OSA-induced hypoxia.
AIM 05Utilize large sleep study databases to validate research findings and improve patient outcomes.
Skills the Lab Values
cell culturemicrovascular modelingbiopsy analysiscardiac function assessmentRNA sequencing
Output against the department
Publications77bottom 11% of dept.526th of 595
this lab
most publishedleast published
Citations3.1kbottom 24% of dept.453rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.