University of Maryland, Baltimore · PharmacologyZhang Lab
Li Zhang · Baltimore, Maryland
Research Focus
The lab led by Dr. Li Zhang focuses on understanding the role of a specific protein, integrin CD11b, in the regression of atherosclerosis, a condition that causes artery hardening and narrowing, leading to cardiovascular diseases. Their research aims to develop new therapeutic strategies to promote the regression of atherosclerotic plaques by investigating the interactions between CD11b, cholesterol transport proteins, and inflammation in macrophages. This work is important for designing more effective treatments that could lower healthcare costs associated with cardiovascular diseases.
atherosclerosisCD11bmacrophagescholesterol effluxinflammationcardiovascular diseasesintegrinslipid-lowering therapyABCA1ApoA1
Research Aims
3AIM 01Examine the role of CD11b in atherosclerosis regression during different disease stages.
AIM 02Investigate how CD11b interacts with ABCA1 and ApoA1 to enhance cholesterol efflux.
AIM 03Develop CD11b-targeting strategies to improve atherosclerosis regression using mouse models.
Skills the Lab Values
murine modelscell cultureimmunohistochemistryWestern blottingflow cytometrygenetic manipulationmolecular cloninglipid profilingRNA isolationPCR
Output against the department
Publications184top 48% of dept.222nd of 462
this lab
most publishedleast published
Citations89ktop 1% of dept.6th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.