University of Delaware · EngineeringMonoclonal Antibody Production Lab
Marianthi Ierapetritou · Newark, Delaware
Research Focus
Dr. Marianthi Ierapetritou's research lab at the University of Delaware focuses on improving the manufacturing of monoclonal antibodies, which are important for many medical treatments. The lab combines experimental work with computational modeling to optimize the processes used in both growing cells and purifying the antibodies. By developing predictive models, the lab aims to make the production process more efficient and reliable, benefiting both industry and regulatory bodies like the FDA.
biomanufacturingmonoclonal antibodiescontinuous processingcomputational modelingcell culturechromatographyprocess optimizationquality assurance
Research Aims
3AIM 01Develop a multiscale model for perfusion bioreactors that captures effects of operational parameters.
AIM 02Optimize continuous chromatographic operations for antibody purification.
AIM 03Create predictive models for determining optimal manufacturing conditions.
Skills the Lab Values
cell culturechromatographyprocess modelingdata analysisexperimental validationbioreactor operationsstatistical analysisrisk assessmentautomation technologysoftware simulation
Output against the department
Publications450top 14% of dept.40th of 278
this lab
most publishedleast published
Citations16ktop 25% of dept.70th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.