University of Arkansas for Medical Sciences · PharmacologyDiabetes and Hypertension Immunology Lab
Yunmeng Liu · Little Rock, Arkansas
Research Focus
Dr. Yunmeng Liu's lab is focused on understanding how diabetes and hypertension are connected through the immune system, particularly looking at T cells. The research aims to uncover the mechanisms behind T cell activation and its impact on these diseases using mouse models. By exploring how certain signaling pathways involving ATP and insulin contribute to this connection, the lab hopes to identify new therapeutic targets to help reduce the risks associated with metabolic syndrome.
T cellsdiabeteshypertensionimmune systemmetabolic syndromecell signalingATPinsulinmouse models
Research Aims
3AIM 01Examine the impact of ATP-P2X7 signaling on CD8 T cell activation and hypertension.
AIM 02Investigate the role of insulin-InsR-Panx1 signaling in chronic T cell activation during diabetes progression.
AIM 03Understand the formation of kidney-resident CD8 T cells in type 2 diabetes and their role in hypertension.
Skills the Lab Values
PCRmouse modelscell cultureflow cytometryWestern blotimmunology techniquessignal transduction assaysgenetic knockout techniquesmetabolic assays
Output against the department
Publications30bottom 3% of dept.450th of 462
this lab
most publishedleast published
Citations251bottom 2% of dept.454th of 462
this lab
most citedleast cited
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