University of Chicago · BiochemistryKeenan Protein Lab
Robert J Keenan · Chicago, Illinois
Research Focus
Dr. Robert J Keenan's lab at the University of Chicago focuses on understanding how membrane proteins are created and folded in cells. These proteins play essential roles in various cellular functions and their improper folding can lead to diseases. The lab's research investigates the molecular mechanisms behind the assembly of multi-pass membrane proteins, crucial for both cell functionality and health. By studying these processes, they aim to provide insights that may help address various human diseases related to membrane protein dysfunction.
membrane proteinsprotein biogenesiscell biologyendoplasmic reticulumtransmembrane proteinsbiochemical mechanismsdisease treatment
Research Aims
5AIM 01Investigate the molecular mechanisms of membrane protein biogenesis.
AIM 02Characterize the novel translocon involved in multi-pass protein insertion.
AIM 03Analyze the folding and assembly processes of membrane proteins at the endoplasmic reticulum.
AIM 04Explore the links between membrane protein misfolding and human diseases.
AIM 05Utilize interdisciplinary approaches to deepen understanding of membrane dynamic processes.
Skills the Lab Values
biochemical assayscell culturegenetic manipulationstructural biology techniquesbioinformaticsWestern blottingmicroscopyprotein purificationdata analysis
Output against the department
Publications226top 35% of dept.137th of 402
this lab
most publishedleast published
Citations13ktop 39% of dept.155th of 402
this lab
most citedleast cited
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