Baylor College of Medicine · GeneticsPark Osteogenesis Lab
Dongsu Park · Houston, Texas
Research Focus
Dr. Dongsu Park's lab at Baylor College of Medicine studies a genetic bone disorder called Osteogenesis Imperfecta (OI), which affects how bones grow and heal. They focus on understanding how changes in a specific type of stem cell, responsible for bone regeneration, are influenced by defects in collagen. The goal is to uncover new insights that could improve treatments for patients with OI, leading to better healing and bone strength.
Osteogenesis Imperfectastem/progenitor cellsbone regenerationcollagencraniofacial abnormalitiesbone healingextracellular matrixanimal modelssingle-cell RNA sequencing
Research Aims
4AIM 01Define the in vivo characteristics and function of periosteal and bone marrow SSPCs in OI mouse models.
AIM 02Identify key OI matrix factors that regulate SSPC function.
AIM 03Investigate how the OI extracellular matrix affects stem cell populations and functions.
AIM 04Explore the implications of altered stem cell behavior on bone healing and regeneration.
Skills the Lab Values
cell culturemouse modelsintravital imagingRNA sequencingstem cell characterizationbone repair assessmentgenetic modification techniquesflow cytometryfluorescence microscopy
Output against the department
Publications73bottom 19% of dept.207th of 259
this lab
most publishedleast published
Citations2.3kbottom 10% of dept.233rd of 259
this lab
most citedleast cited
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