UAUniversity of Arkansas · Engineering
Richardson Fibrosis Lab
William James Richardson · Fayetteville, Arkansas
Research Focus
Dr. William James Richardson's lab focuses on understanding and predicting cardiac fibrosis, which is a significant factor in heart failure. The lab uses advanced computational models and experimental techniques to study how mechanical and biochemical signals affect heart tissue. By integrating patient-specific data, their goal is to improve personal treatment options for individuals with heart failure and develop new therapeutic strategies.
cardiac fibrosisheart failuremechanobiologypersonalized medicinebiochemical signalingcell culturecollagen regulationcomputational modelingtissue engineering
Research Aims
3AIM 01Identify signaling feedback loops in cardiac fibroblasts under dynamic mechanical conditions.
AIM 02Test personalized treatment responses using patient-specific in vitro cultures.
AIM 03Evaluate prognostic biomarkers for predicting fibrosis and patient outcomes in heart failure.
Skills the Lab Values
computational modelingcell culturemechanical stimulation techniquesbiochemical assaysbiomechanicsdata analysis using Pythonserum biomarker evaluationin vitro testingfeedback loop analysis