Drexel University · Microbiology & ImmunologyMalaria Metabolism Lab
Hangjun Ke · Philadelphia, Pennsylvania
Research Focus
Dr. Hangjun Ke's research lab focuses on understanding the biology of malaria parasites, particularly during the ring stage of their lifecycle. This stage is crucial because it allows the parasite to evade the immune system and is less responsive to existing antimalarial drugs. By studying the unique ways these parasites generate energy without ATP, the lab aims to identify new strategies to combat malaria and improve treatment outcomes.
MalariaPfVP1Proton PumpEnergy MetabolismPlasmodium falciparumRing StageDrug ResistancePolyphosphate Metabolism
Research Aims
3AIM 01Investigate the impact of PfVP1's loop sequences on its proton pumping functionality.
AIM 02Examine polyphosphate metabolism and PPi metabolism to understand the energy source for PfVP1.
AIM 03Reveal how the ring stage parasite survives within red blood cells after invasion.
Skills the Lab Values
PCRCell CultureMolecular CloningFlow CytometryMass SpectrometryPolyacrylamide Gel ElectrophoresisMicroscopyBioinformaticsBiochemical Assays
Output against the department
Publications39bottom 6% of dept.454th of 486
this lab
most publishedleast published
Citations1.1kbottom 6% of dept.457th of 486
this lab
most citedleast cited
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